Shape GWAS Study

Investigates 8 subcortical brain regions across left and right hemispheres using Highly Efficient Imaging Genetics (HEIG) for voxel-level GWAS. Preserves 85–90% of total variance at a fraction of the storage cost.

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6 shape features measured

F1 Radial Distance
F2 mTBM1
F4 mTBM3
F5 Determinant
F6 Max Eigenvalue
F7 Min Eigenvalue

Regions & vertices

Accumbens, Amygdala, Caudate, Hippocampus, Pallidum, Putamen, Thalamus — 15,000 vertices each hemisphere.
Ventricle — 21,764 (L) / 23,584 (R) vertices.

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Left hemisphere — HEIG Miami plot

Right hemisphere — HEIG Miami plot